abstract：:In the United States, federal and local governments have attempted to contain the spread of Coronavirus Disease 2019 (COVID-19) by implementing a variety of policies such as stay-at-home orders and mask mandates. Perceptions can influence behaviors; therefore, it is important to understand how people perceive the stri...

authors： Lee S,Peng TQ,Lapinski MK,Turner MM,Jang Y,Schaaf A

更新日期：2021-12-01 00:00:00

abstract：:Phytopathogenic oomycetes are known to successfully infect their hosts due to their ability to secrete effector proteins. Of interest to many researchers are effectors with the N-terminal RxLR motif (Arginine-any amino acid-Leucine-Arginine). Owing to advances in genome sequencing, we can now comprehend the high level...

authors： Chepsergon J,Motaung TE,Moleleki LN

更新日期：2021-12-01 00:00:00

abstract：:Aging well is a priority in Canada and globally, particularly for older Indigenous adults experiencing an increased risk of chronic conditions. Little is known about health promotion interventions for older Indigenous adults and most literature is framed within Eurocentric paradigms that are not always relevant to Ind...

authors： Oosman S,Nisbet C,Smith L,Abonyi S

更新日期：2021-12-01 00:00:00

abstract：:The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine clusters displayed...

authors： Evangelista TCS,López Ó,Ferreira SB,Fernández-Bolaños JG,Sydnes MO,Lindbäck E

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Out-of-hospital cardiac arrest (OHCA) remains one of the most common causes of death. There is a scarcity of evidence concerning the prevalence of bacteraemia in cardiac arrest patients presenting to the Emergency Department (ED). We aimed to determine the prevalence of bacteraemia in OHCA patients presentin...

authors： Abou Dagher G,Bou Chebl R,Safa R,Assaf M,Kattouf N,Hajjar K,El Khuri C,Berbari I,Makki M,El Sayed M

更新日期：2021-12-01 00:00:00

abstract：:Farm managers' decision to cull dairy cows is based on the cows' milk production, history of disorder(s), and reproductive performance, each of which affects dairy cows' lifetime (herd life and productive lifespan). We investigated the relationships among the incidence of clinical mastitis (CM), the reproductive perfo...

authors： Kurokawa Y,Okita M,Kubota H,Tsumiyama Y,Chikamatsu I,Tanaka A,Obitsu T,Kawamura K

更新日期：2021-12-01 00:00:00

abstract：:Purpose: Although it is believed that involving the workplace and stakeholders in return-to-work interventions is beneficial, Norwegian occupational rehabilitation programmes rarely do. During 2015-2016, Hysnes Rehabilitation Centre provided inpatient multimodal occupational rehabilitation, including workplace meeting...

authors： Klevanger NE,Fimland MS,Rise MB

更新日期：2021-12-01 00:00:00

abstract：:A large number of studies have shown that microRNA (miRNA) has an important relationship with the occurrence and development of colorectal cancer (CRC), but its specific molecular mechanism has not been fully elucidated. This study is to explore the influence of miR-506-3p on the malignant behavior of CRC and its unde...

authors： Ai L,Luo X,Yan X,Jiang S

更新日期：2021-12-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT)-related long non-coding RNAs (lncRNAs) may be exploited as potential therapeutic targets in gliomas. However, the prognostic value of EMT-related lncRNAs in gliomas is unclear. We obtained lncRNAs from The Cancer Genome Atlas and constructed EMT-related lncRNA co-expression netw...

authors： Tao C,Luo H,Chen L,Li J,Zhu X,Huang K

更新日期：2021-12-01 00:00:00

abstract：:This experiment was conducted to investigate the effects of sodium humate (HNa) and glutamine (Gln) alone or combined supplementation on growth performance, diarrhea incidence, blood parameters, and intestinal microflora of weaned Holstein calves. In a 14-day experiment, 40 calves at 51 ± 3 days of age were randomly a...

authors： Wang D,Du Y,Wang S,You Z,Liu Y

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Eosinophils in peripheral blood are one of the emerging biomarkers in chronic obstructive pulmonary disease (COPD) patients. However, when analysing the relationship between peripheral eosinophilia and COPD prognosis, highly variable results are obtained. The aim of our study is to describe the serum eosinop...

authors： Martínez-Gestoso S,García-Sanz MT,Calvo-Álvarez U,Doval-Oubiña L,Camba-Matos S,Salgado FJ,Muñoz X,Perez-Lopez-Corona P,González-Barcala FJ

更新日期：2021-12-01 00:00:00

abstract：:This study was designed to study functions of Circ_0000020 during osteogenic differentiation. First, we used RT-qPCR to detect the expression of Circ_0000020, miR-142-5p and osteogenesis-related genes, whereas western blot analysis detected the expression of osteogenesis markers after the osteogenic differentiation of...

authors： Zhou R,Miao S,Xu J,Sun L,Chen Y

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:In autosomal dominant polycystic kidney disease (ADPKD), endothelial dysfunction (ED) is common and occurs much earlier than kidney function impairment. The impact of smoking on ED in ADPKD patients has not been previously studied. The aim of this study was to investigate the potential contribution of smokin...

authors： Gul CB,Yildiz A,Sag S,Oruc A,Ersoy A,Gullulu S

更新日期：2021-12-01 00:00:00

abstract：:This study evaluated pembrolizumab-conjugated, doxorubicin (DOX)-loaded microbubbles (PDMs) in combination with ultrasound (US) as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Pembrolizumab, a monoclonal CD20 antibody, was attached to the surfaces of DOX-loa...

authors： Liu H,Li X,Chen Z,Bai L,Wang Y,Lv W

更新日期：2021-12-01 00:00:00

abstract：:Lymphocyte-specific protein tyrosine kinase (Lck), a non-receptor Src family kinase, has a vital role in various cellular processes such as cell cycle control, cell adhesion, motility, proliferation, and differentiation. Lck is reported as a key factor regulating the functions of T-cell including the initiation of TCR...

authors： Elkamhawy A,Ali EMH,Lee K

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Valeriana jatamansi Jones [syn. V. wallichii DC, (Valerianaceae)] (VJJ) is used to treat depression. OBJECTIVE:To explore the effects of total iridoids of VJJ extract (TIV) on chronic unpredictable mild stress (CUMS) in mice. MATERIALS AND METHODS:VJJ roots and rhizomes were extracted with 70% ethanol. CUMS r...

authors： Zhang L,Wang L,Huang L,Zhao Y,Ding H,Li B,Wen L,Xiong W,Liu Y,Zhang T,Zhang L,Wu L,Xu Q,Fan Y,Wei G,Yin Q,Chen Y,Zhang T,Yan Z

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Ischaemia caused by lower extremity artery stenosis is the main cause of peripheral artery disease (PAD) in patients with diabetes. Trimetazidine (TMZ) has traditionally been used as an anti-ischaemic drug for coronary artery disease. The effect of TMZ on PAD in a diabetic animal model and the underlying mol...

authors： Yang Y,Xu Q,Li T,Shao S

更新日期：2021-12-01 00:00:00

abstract：:Metastatic lung cancer is the leading cause of death for cancer patients. Although many chemical drugs were developed for cancer treatment, metastatic cancer mortality did not decrease significantly. In this article, we designed an Au clusters (AuCs) modified by cyclic RGD peptides which well target the integrin of hu...

authors： He Z,Du Z,Zhang C,Gao X,Xing G

更新日期：2021-12-01 00:00:00

abstract：:Nanomaterials with intrinsic enzyme-mimicking characteristics, refered to as nanozymes, have become a hot research topic owing to their unique advantages of comparative low cost, high stability and large-scale preparation. Among them, Single-atom nanozymes (SAzymes), as novel nanozymes with abundant atomically dispers...

authors： Chi L,Zhang Y,Hua Y,Xu Q,Lv M,Wang H,Xie J,Yang S,Yong Y

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the functional outcome in...

authors： Maksimova MY,Ivanov AV,Virus ED,Nikiforova KA,Ochtova FR,Suanova ET,Kruglova MP,Piradov MA,Kubatiev AA

更新日期：2021-12-01 00:00:00

abstract：:The degree of intramuscular adipose tissue accumulation is one of the factors affecting meat quality. Accumulation of adipocytes is also observed under the pathological condition of skeletal muscle such as muscular dystrophy and sarcopenia. The origin of adipocytes seen in skeletal muscle is mesenchymal progenitor cel...

authors： Yamanouchi K,Nakamura K,Takeuchi S,Hosoyama T,Matsuwaki T,Nishihara M

更新日期：2021-12-01 00:00:00

abstract：:Studies on fabricating robust superhydrophobic surfaces by a low-cost method have been rare, despite the recent demand for nature-inspired superhydrophobic surfaces including self-healing ability in various industrial applications. Herein, we propose a fabrication method for self-healable, robust superhydrophobic nano...

authors： Park YA,Ha YG

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Few studies have been published about specialty-specific fourth-year medical student leadership in any discipline. This paper provides insight from pediatric educators about the current status and recommendations for pediatric-specific fourth-year leaders. OBJECTIVE:To identify the prevalence of pediatric f...

authors： Rideout M,Dawlett M,Plant J,Chitkara M,Trainor JL

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Peritonitis is one of the most serious complications of peritoneal dialysis (PD). This study aimed to explore the relationship between peritoneal transport status and the first episode of peritonitis, as well as the prognosis of patients undergoing continuous ambulatory peritoneal dialysis (CAPD). METHOD:A ...

authors： Hu J,Zhang H,Yi B

更新日期：2021-12-01 00:00:00

abstract：:ScPO₄:Eu3+, Tb3+ phosphors with tuned emission color were prepared through high temperature solid-state reaction. The structure, morphology and photoluminescence properties of the title samples were collected by XRD, SEM and fluorescence spectrophotometer, respectively. Co-doping Eu3+ and Tb3+ in ScPO₄ does not change...

authors： Zhou J,Zhao JW,Ren SL,Dong J

更新日期：2021-12-01 00:00:00

abstract：:With the rapid development of the electronics industry, electronic products based on silicon and glass substrates electronic products will gradually be unable to meet the rising demand. Flexibility, environmental protection, and low costs are important for the development of electronic products. In this study, an effi...

authors： Wang Q,Li M,Xie Y,Ou Y,Zhou W

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Laurolitsine is an aporphine alkaloid and exhibits potent antihyperglycemic and antihyperlipidemic effects in ob/ob mice. OBJECTIVE:To investigate the pharmacokinetics, tissue distribution and excretion of laurolitsine. MATERIALS AND METHODS:A LC-MS/MS method was established and validated to determine lauroli...

authors： Tan YF,Wang RQ,Wang WT,Wu Y,Ma N,Lu WY,Zhang Y,Zhang XP

更新日期：2021-12-01 00:00:00

abstract：:Magnolia sieboldii K. Koch is endemic to China and has high medicinal and ornamental values. However, its seed exhibits morphophysiological dormancy, and the molecular mechanisms of which are not clearly understood. To reveal the regulation mechanism of the ABA signal in seed dormancy, the M. sieboldii ABA receptor Py...

authors： Zeng WQ,Sun HT,Wang L,Lu XJ,Zhang XL

更新日期：2021-12-01 00:00:00

abstract：:A series of 1,2,3-trisubstituted indolizines (2a-2f, 3a-3d, and 4a-4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b-2d, 3a-3d, and 4a-4c were active against the H37Rv-MTB strain with min...

authors： Venugopala KN,Chandrashekharappa S,Deb PK,Tratrat C,Pillay M,Chopra D,Al-Shar'i NA,Hourani W,Dahabiyeh LA,Borah P,Nagdeve RD,Nayak SK,Padmashali B,Morsy MA,Aldhubiab BE,Attimarad M,Nair AB,Sreeharsha N,Haroun M,Shas

更新日期：2021-12-01 00:00:00

abstract：Background:This study was conducted to demonstrate the effectiveness and safety of herbal medicine and acupuncture treatment in unexplained infertile females. Methods:One hundred patients were recruited from 3 Korean Medicine hospitals in Korea and they voluntarily signed informed consent agreements. Participants took...

authors： Choi SJ,Kim DI,Yoon SH,Lim CY,Lee JM,Choe CM

更新日期：2021-12-01 00:00:00

abstract：:Ultraviolet B (UVB) is one of the most common exogenous factors in skin aging, especially photoaging. Once a large amount of UVB accumulates within a short period of time, skin tissue can become inflamed. It has also been found in clinics that platelet-rich plasma (PRP) can promote wound repair; therefore, the aim of ...

authors： Park G,Qian W,Zhang MJ,Chen YH,Ma LW,Zeng N,Lu Q,Li YY,Ma WW,Yin XF,Zhou BR,Luo D

更新日期：2021-12-01 00:00:00

abstract：:Circular RNA (circRNA), a recently identified endogenous non-coding RNA molecule, regulates gene expression in mammals. At the current stage, the expression and function of circRASSF2 in breast cancer (BC) have not been clarified. According to our study, it is found that circRASSF2 sequences contain miR-1205 binding s...

authors： Zhong W,Bao L,Yuan Y,Meng Y

更新日期：2021-12-01 00:00:00

abstract：:Ultrasound (US) is reported to improve the delivery efficiency of drugs loading onto large nanoparticles due to the sonoporation effect. Microbubbles (MBs) can be used as contrast agents of US expanding and contracting under low-amplitude US pressure waves. Ultrasound-stimulated microbubbles (USMBs) therapy is a promi...

authors： Shi J,Fu C,Su X,Feng S,Wang S

更新日期：2021-12-01 00:00:00

abstract：:Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is expertly adapted to thrive in a wide variety of environments, and in the process, making it a notorious opportunistic pathogen. Apart from the extensively studied ch...

authors： Morin CD,Déziel E,Gauthier J,Levesque RC,Lau GW

更新日期：2021-12-01 00:00:00

abstract：:In ruminants, the ruminal epithelium not only has the function of absorbing nutrients but also is an important tissue to prevent harmful substances in the rumen from entering the blood circulation. Thus, the normal function of ruminal epithelium is critical for ruminants. However, subacute ruminal acidosis induced by ...

authors： Ma J,Shah AM,Wang Z,Fan X

更新日期：2021-12-01 00:00:00

abstract：:Both theory and experimental data from pathogens suggest that the production of transmission stages should be strongly associated with virulence, but the genetic bases of parasite transmission/virulence traits are poorly understood. The blood fluke Schistosoma mansoni shows extensive variation in numbers of cercariae ...

authors： Le Clec'h W,Chevalier FD,McDew-White M,Menon V,Arya GA,Anderson TJC

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:We carried out this study to demonstrate the effects of outcome sensitivity, participant exclusions, and covariate manipulations on results of the epidemiological analysis of coronary heart disease (CHD) and its behaviour-related risk factors. MATERIAL AND METHODS:Our study population consisted of 1592 54-y...

authors： Voutilainen A,Brester C,Kolehmainen M,Tuomainen TP

更新日期：2021-12-01 00:00:00

abstract：:Cronobacter sakazakii is a food-borne, conditionally pathogenic bacterium that mainly infects neonates, especially premature infants. Previous studies have indicated that an important route of infection for C. sakazakii is through infant formula, suggesting a high stress resistance of the bacterium. RpoS is a σ-factor...

authors： Zhan J,Qiao J,Wang X

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Lipopolysaccharide (LPS) exacerbates systemic inflammatory responses and causes excessive fluid leakage. 2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) has been revealed to protect against LPS-induced vascular inflammation and endothelial hyperpermeability in vitro. OBJECTIVE:This study assesses the in vivo pr...

authors： Chan YH,Musa NF,Chong YJ,Saat SA,Hafiz F,Shaari K,Israf DA,Tham CL

更新日期：2021-12-01 00:00:00

abstract：:Influenza is a respiratory viral infection that causes significant morbidity and mortality worldwide. The innate immune cell response elicited during influenza A virus (IAV) infection forms the critical first line of defense, which typically is impaired as we age. As such, elderly individuals more commonly succumb to ...

authors： Harpur CM,Le Page MA,Tate MD

更新日期：2021-12-01 00:00:00